Every issue of The Alkaloid — the weekly independent newsletter on cannabis, psychedelics, and plant medicine.
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Two clinical trials of lion's mane both gave subjects three grams a day. One of them used ten times more mushroom than the other. Seventeen years of research, seven small trials, and still no agreement on what a dose is. Plus Curaleaf goes hostile on Aurora, and Yale prices federal legalization.
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PsiDeR was built to answer whether the NHS could run a psilocybin trial at all. It could. The 12.92-point depression result everyone reported is a secondary outcome, and the researchers said so plainly. Their press office left that part out. Plus: the Senate blinks on hemp.
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Past-month cannabis use among Minnesota teens fell from 13% to 5% across twelve years of steadily looser law, and the predicted spike never came. The decline also never reached Native, LGBTQ+ or low-income students, who were three times more likely to use in 2013 and still are today.
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Researchers pooled 28 studies covering 937 CBD products and found just 31.3 percent contained what the label claimed. Topicals came in at 13.8 percent. Plus undisclosed THC, synthetic cannabinoids, heavy metals, and why the number on the box can be wrong in four different ways.
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Humans have used peyote for 5,700 years, yet mescaline is the psychedelic neuroscience knows least. A new Northeastern brain scan shows the oldest trip has a signature all its own — and Big Pharma just bet up to $3.8B on its molecular cousins.
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For years, home growers prized a potent magic mushroom called Natal Super Strength. Nobody had ever named it. New DNA work shows it is a separate species, and its family tree pushes the origins of the world's favorite psychedelic mushroom back more than a million years.
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What if the trip was never the point? A new class of compounds promises the brain-rewiring of psychedelics without the hallucination, and the first non-tripping antidepressant is heading for trials you can run from your own couch.
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Scientists finally caught the munchies in the act. A new study shows cannabis turns up the brain's reward for food, spikes the hunger hormone, and sharpens taste. The same circuit could feed people who can't eat.
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Psychedelic science spent sixty years studying the young. A new UC Berkeley study finally hands the eye mask to people between 60 and 85 — and asks whether an old brain can still change its mind.
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A lab in Israel engineered one tobacco plant to make psilocybin, DMT, bufotenin, 5-MeO-DMT, and psilocin at once. The molecules just left the mushroom and the toad behind. What that means for cost, supply, and a drug law written when the drug and its source were the same thing.
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Last fall Congress redefined hemp and capped legal products at 0.4 milligrams of THC. The rule erases an estimated 95 percent of the market by November. Now the same White House that signed it is asking Congress to carve out an exception before the deadline it created.
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The FDA lost its commissioner in May. Four weeks from now, the agency is supposed to help decide whether all marijuana moves to Schedule III. The most powerful job in American drug policy is being done by a caretaker, and almost nobody is talking about it.